It was in 1961 that the Sisters in Malawi ventured into the neighboring country of Northern Rhodesia, which, in 1964, would become Zambia.
In 1961, their first mission was Kasiya where they maintained a commercial secondary school with boarding. Four missionaries founded Élisabeth Bruyère Convent to minister in education and good works.
In 1962, in Fort Jameson (now Chipata), St. Monica Secondary Boarding School opened, giving much hope for the future of young girls.
From 1964, there would no longer be mention of Nyassaland, nor of Northern Rhodesia, nor of Fort Jameson, but of Malawi, Zambia and Chipata.
In 1966, in Mpanshya, the Sisters accept the administration of St. Luke Hospital founded by the Jesuit Fathers. This was a highly humanitarian undertaking that answered a pressing need. The Sisters would leave this place in 1978.
In 1967, two African Sisters open St. Mary Convent in Monze where they will be entrusted with a primary school, a Home Economics School, a catechetical center and social services. They would leave the area in 1972.
In 1971 and in 1972, the results of the Cambridge exams acclaimed St. Monica Secondary School in first place in all of the Eastern Province.
The year 1980 saw the opening of Élisabeth Bruyère Convent in Chipata. The Regional Leadership chose to transfer the novitiate from Ludzi to Chipata for the formation of young candidates.
In 1983, the Bishop of Chipata, His Excellency Medardo J. Mazombwe requested Congregation to build a health center in a rural area. The General Council agrees and a letter of approval arrives in August. This would become Our Lady of Peace Convent with a hospital-clinic in Kalichero.
Mount St. Joseph Convent opened in Chipata in 2008. It would become the Regional House as well as a place to receive Sisters in transit.
On May 20, 2015, St. John XXIII convent was blessed in Lumimba Parish in Lundazi.
On January 1, 2016, a new region was created for the Sisters in Zambia: Saint John Paul II Region.